(all of this is tested in a real game, not studio)
I enabled FilteringEnabled in my game. I placed a ClickDetector into a brick. I made a Server Script that says to delete the Baseplate when the brick is clicked. When you click the brick, nothing happens.
Now, I disabled FilteringEnabled in my game and did the same stated above. However, now it works! Does this mean ClickDetectors are now handled by the client? Because, the wiki still says it's only handled by ServerScripts:
"The MouseClick event must be handled by a Script."
http://wiki.roblox.com/index.php?title=API:Class/ClickDetector
Try it for yourself if you don't believe me, I could be wrong.